The TRAPP Complex Is a Nucleotide Exchanger for Ypt1 and Ypt31/32
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چکیده
منابع مشابه
The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32.
In yeast, the Ypt1 GTPase is required for ER-to-cis-Golgi and cis-to-medial-Golgi protein transport, while Ypt31/32 are a functional pair of GTPases essential for exit from the trans-Golgi. We have previously identified a Ypt1 guanine nucleotide exchange factor (GEF) activity and characterized it as a large membrane-associated protein complex that localizes to the Golgi and can be extracted fro...
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15 صفحه اولTRAPP Complexes in Secretion and Autophagy
TRAPP is a highly conserved modular multi-subunit protein complex. Originally identified as a "transport protein particle" with a role in endoplasmic reticulum-to-Golgi transport, its multiple subunits and their conservation from yeast to humans were characterized in the late 1990s. TRAPP attracted attention when it was shown to act as a Ypt/Rab GTPase nucleotide exchanger, GEF, in the 2000s. C...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2000
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.11.12.4403